Cambridge, UK, 25th January 2016 / Sciad NewswireDomainex Ltd., a small-molecule drug discovery company, and Cresset Discovery Services, a services company for small molecule discovery and design, today announced an alliance to provide their customers with world-class laboratory-based and computational drug discovery services through a seamless combination of their respective capabilities in chemistry and biology.

The alliance will give clients fully-integrated access to the renowned expertise of Domainex in protein expression, biochemical assays, hit identification, computational and medicinal chemistry; and to Cresset’s world-class approach to hit identification and drug design using its proprietary computational technologies.

Eddy Littler, Chief Executive Officer of Domainex said, “We are delighted to be announcing this alliance with Cresset. The combination of Domainex’s drug discovery skills and the computational chemistry technologies and expertise of Cresset means that together we can offer customers an unrivalled capability to identify novel hit compounds against important drug targets, and to progress these all the way to candidate drugs.  In particular Cresset’s patented field point technology and associated ligand-based approaches to targets such as GPCRs and ion-channels will perfectly complement Domainex’s own expertise in target areas such as enzymes and protein-protein interactions. We look forward to developing our relationship, and enhancing the success of our client programmes through the combination of our skills and competences.”  

He added, “We have recently announced that we will be moving our laboratories to a new and larger facility at Chesterford Research Park. Our alliance with Cresset provides a complementary expansion of the range of computational technologies that we can apply to client projects, and directly integrates with our well-established skills in assay development,  medicinal and computational chemistry”.

Rob Scoffin, Chief Executive Officer of Cresset, said “we are very excited about the opportunity to partner with another world-class research services company in order to offer unrivalled capabilities in drug discovery and development. We are able to provide integrated services which will include access to Cresset’s existing applications as well as our pipeline of cutting edge computational science and yet-to-be-commercialised methods”.


Editors Notes

About Domainex

Domainex Ltd. is a Cambridge-based small-molecule drug discovery company that provides integrated drug discovery services to pharmaceutical, biotechnology and academic partners globally. Services cover a wide span of the drug discovery value chain, from disease target validation to pre-clinical candidate nomination. Domainex’s services include recombinant protein expression and use of its proprietary technology platform, Combinatorial Domain Hunting to identify soluble protein fragments for structural biology and assay development. Hit finding activities encompass assay development and screening utilising its Bioassay Builder and LeadBuilder portfolios. The core of the service platform is undertaking multi-parameter medicinal chemistry optimisation of hits and leads under the mantra ‘every compound counts’, which can save up to 30% of average industry time.

Additionally, Domainex is investing in developing its own therapeutic compounds for out-licensing in two specific areas: 1) Inhibitors of the kinases TBK1 & IKK epsilon to treat inflammatory conditions such as COPD and psoriasis; 2) The emerging epigenetic target class of lysine methyltransferases potentially implicated in oncology, where to date Domainex has built a portfolio of drug discovery assets encompassing novel chemical matter, proprietary assays and X-ray crystal structures.

For more information please visit

About Cresset Discovery Services

Cresset Discovery Services offers a powerful combination of human expertise, computational biology and computational chemistry approaches to solve high-value problems in drug discovery. Our proven commercial software and our cutting-edge research software deliver key insights and impactful results.

For more information, please visit

For more information please contact


Eddy Littler
Chief Executive Officer
Tel: +44 (0)7584 578024


Sue Peffer
Marketing Manager
Tel: +44 (0)1223 858890

For media relations please contact

Sciad For Domainex

Deborah Cockerill
Tel: +44 (0)7973 950376

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